By Sanjay J. Mathew,Jr., Carlos A. Zarate
This ebook brings jointly a world team of clinicians and researchers from a wide swath of inter-related disciplines to supply the main updated information regarding scientific and preclinical examine into ketamine and second-generation “ketamine-like” fast-acting antidepressants.
Currently to be had antidepressant medicines act via monoaminergic platforms, are useless for lots of members struggling with melancholy, and are linked to a behind schedule onset of height efficacy of numerous months. The unforeseen emergence of ketamine, an anesthetic N-methyl-D-aspartate (NMDA) receptor antagonist, as a rapid-acting antidepressant has reinvigorated CNS drug discovery examine and catalyzed research in sufferer populations traditionally neglected in antidepressant drug improvement courses, fairly treatment-resistant sufferers and people with suicidality. fresh and educational learn efforts have coalesced to discover NMDA receptor and glutamatergic molecular pursuits that lack ketamine’s psychotomimetic unintended effects and abuse legal responsibility yet keep its speedy onset of efficacy. in spite of the fact that, many basic questions stay in regards to the neurobiological mechanisms underlying ketamine’s speedy antidepressant results and the complicated patience of advantages saw in a few sufferers following a unmarried dose.
This ebook examines how insights from those stories are forging new conceptual types of the neurobiology of stress-related affective, anxiousness, and addictive problems and the character of therapy resistance. It additionally discusses how ketamine’s speedy antidepressant results offer a systematic platform to facilitate innovation in medical trial designs touching on sufferer choice, number of keep watch over crew, end result measures, and dose-optimization. This e-book brings jointly facts and insights from this swiftly increasing and terribly promising box of analysis. Readers may be in a position to extract built-in topics and invaluable insights from the fabric contained in those diversified chapters and enjoy the paradigm-shifting contributions of ketamine to trendy psychiatry and scientific neuroscience research.
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Extra resources for Ketamine for Treatment-Resistant Depression: The First Decade of Progress
Ketamine for Treatment-Resistant Depression: The First Decade of Progress by Sanjay J. Mathew,Jr., Carlos A. Zarate