Astrocytes in (Patho)Physiology of the Nervous System by Vladimir Parpura,Philip G. Haydon PDF

By Vladimir Parpura,Philip G. Haydon

ISBN-10: 1489979115

ISBN-13: 9781489979117

Astrocytes have been the unique neuroglia that Ramón y Cajal visualized in 1913 utilizing a gold sublimate stain. This stain certain intermediate filaments that we now understand consist quite often of glial fibrillary acidic protein, a protein used this day as an astrocytic marker. Cajal defined the morphological range of those cells with a few ast- cytes surrounding neurons, whereas the others are in detail linked to vasculature. we begin the booklet by way of discussing the heterogeneity of astrocytes utilizing modern instruments and via calling into query the belief by way of classical neuroscience that neurons and glia are derived from particular swimming pools of progenitor cells. Astrocytes have lengthy been ignored as energetic contributors in intercellular communique and knowledge processing within the relevant frightened method, partially because of their loss of electric excitability. The persist with up chapters evaluation the “nuts and bolts” of ast- cytic body structure; astrocytes own a various collection of ion channels, neu- transmitter receptors, and shipping mechanisms that permit the astrocytes to reply to the various comparable indications that act on neurons. in view that astrocytes can notice chemical transmitters which are published from neurons and will unlock their very own extracellular indications there's an expanding know-how that they play physiological roles in regulating neuronal job and synaptic transmission. as well as those physiological roles, it really is changing into more and more well-known that astrocytes play severe roles in the course of pathophysiological states of the worried procedure; those states comprise gliomas, Alexander illness, and epilepsy to say a few.

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Astrocytes in (Patho)Physiology of the Nervous System by Vladimir Parpura,Philip G. Haydon

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