Alex Dmitrienko PhD,Gary G. Koch PhD,Alex Dmitrienko,Gary G.'s Analysis of Clinical Trials Using SAS: A Practical Guide, PDF

By Alex Dmitrienko PhD,Gary G. Koch PhD,Alex Dmitrienko,Gary G. Koch

ISBN-10: 162959847X

ISBN-13: 9781629598475

research of medical Trials utilizing SAS®: a realistic consultant, moment version bridges the space among sleek statistical technique and real-world medical trial functions. instructional fabric and step by step directions illustrated with examples from real trials serve to outline correct statistical techniques, describe their medical trial purposes, and enforce the techniques speedily and successfully utilizing the ability of SAS. subject matters replicate the foreign convention on Harmonization (ICH) instructions for the pharmaceutical and handle vital statistical difficulties encountered in scientific trials. frequent tools are coated, together with dose-escalation and dose-finding tools which are utilized in section I and part II scientific trials, in addition to vital trial designs and research concepts which are hired in section II and part III medical trials, resembling multiplicity adjustment, info tracking, and strategies for dealing with incomplete facts. This booklet additionally positive factors thoughts from medical trial specialists and a dialogue of correct regulatory guidelines.
This new version contains extra examples and case reports, new ways for addressing statistical difficulties, and the subsequent new technological updates:

SAS approaches utilized in team sequential trials (PROC SEQDESIGN and PROC SEQTEST)
SAS systems utilized in repeated measures research (PROC GLIMMIX and PROC GEE)
macros for imposing a vast variety of randomization-based tools in scientific trials, acting advanced multiplicity alterations, and investigating the layout and research of early section trials (Phase I dose-escalation trials and part II dose-finding trials)

Clinical statisticians, examine scientists, and graduate scholars in biostatistics will tremendously enjoy the many years of scientific learn adventure and the ready-to-use SAS macros compiled during this book.

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Analysis of Clinical Trials Using SAS: A Practical Guide, Second Edition by Alex Dmitrienko PhD,Gary G. Koch PhD,Alex Dmitrienko,Gary G. Koch


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